Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. Implications for H-2- restricted recognition

Selective Turnover and Shedding of H-2K and H-2D Antigens is Controlled by the Major Histocompatibility Complex

Impl icat ions for H - 2 - Restr ic ted Recogni t ion * BY STEPHEN

Genes mapping in the major histocompatibility complex (MHC) 1 regulate the cytotoxic response of murine lymphoid cells to foreign membrane-bound antigens. Cytotoxic T cells recognize viruses (1, 2), minor histocompatibility antigens (3, 4), and trinitrophenol (TNP) (5, 6) in association with H-2K and H-2D region gene products. This coordinate recognition of H-2 products and foreign antigens res...

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis

Radiation chimeras prepared by injecting H-2 heterozygous F1 stem cells into lethally irradiated parental hosts show a marked, but not absolute, preference for host-type H-2 antigens in the H-2-restricted cytotoxic T lymphocyte (CTL) response to minor histocompatibility (minor H) antigens. We have selected for the anti-minor HCTL that are restricted to the parental H-2 type absent from the chim...

H-2l-restricted Recognition of Viral Antigens

A large body of evidence exists demonstrating that the recognition of viral antigens by cytotoxic thymus (T) -derived lymphocytes (CTL) 1 is virus specific and restricted by gene products encoded in the major histocompatibility complex (1). In the mouse, these restricting genes have been mapped to the H-2K and H-2D regions (1). Indeed, a single mutation in one of these loci can result in failur...

In the 1 - 1 - 2 d Haplotype , Anti - Vesicular Stomati t is Virus Cytotoxic T Cells Are Restr icted

A large body of evidence exists demonstrating that the recognition of viral antigens by cytotoxic thymus (T) -derived lymphocytes (CTL) 1 is virus specific and restricted by gene products encoded in the major histocompatibility complex (1). In the mouse, these restricting genes have been mapped to the H-2K and H-2D regions (1). Indeed, a single mutation in one of these loci can result in failur...